Saturday, May 30, 2009

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Link to the same post in the new blog: Herbs | Temulawak / Wild Ginger an Empirical testing to Clinical

Herbs | Temulawak / Wild Ginger an Empirical testing to Clinical

Wild ginger Temulawak (Curcuma xanthorhiza roxb)
Wild ginger / Temulawak (Curcuma xanthorhiza roxb) is a medicinal plant native Indonesia. Wild Ginger / temulawak included in the ginger family (zingiberaceae), although there, the official distribution of the plant Curcuma javanica as this, only limited on the island of Java, Maluku and Kalimantan. Temulawak grow as a bush not trunked. Start from base of leaf stalk is create a long spring. Higher plants between 2 to 2.5 meters. Long round leaves, like banana leaves.

Since a long times ago temulawak has been used as a febrifuge, stimulate appetite, treat jaundice, diarrhea, mag, flatulence, and weary. Last known, temulawak can also lower blood fat, prevent blood clotting as antioxidants, and maintain health by increasing the immune power. Some benefits are evident and the clinical end.

Temulawak / wild ginger Protect Heart

Pulp (rhizome) temulawak compound contains several chemicals, including atsiri oil fellandrean and turmerol, chamfer, glucosidal, foluymetik carbinol, and curcumin. Curcumin known as the womb that gives many benefits, especially as anti hepototoksik and antioxidants.

A study reported in the animal experiment, the strong curcumin prevent enzyme cytochrome 4501A1/1A2 in the heart. Isoenzim this enzyme is involved in several toxin bioactive including benzo [a] pyrene. Curcumin also found to prevent the formation of kovalen association between cytochrome P450 and DNA. And, the researchers concluded that curcumin can prevent carcinogenesis by chemical modulate the function of P450.

In addition, curcumin also found to offer heart protection against alcohol toxicities. This effect is evident in a study conducted on mice that being inducted with 25% ethanol. Mice that have curcumin 80 mg / kg BB decreased heart rate and enzyme acid reactive products tiobarbiturat. In addition, a study also shows, curcumin reduce liver damage through reduction of peroxides lipid. This is observed in the rat heart has been inducted with fe. Still based on pre-clinical studies, reported curcumin activities also increase glutathione-S-transferase. This enzyme is important in the process of detoxification.

Curcumin Clinical Test

A clinical test that is not so great has been done in the country to see the benefits curcumin in improving heart function. This study involved 38 patients about heart trouble or have a value of SGOT and SGPT in the top 5 from the normal areas (Bogor, Bandung, Semarang, Solo, Surabaya, Palembang and Jakarta). Patients given combination curcumin 25 mg, 100 mg essential phospholipid, and vitamin E 100 mg. Studies using this method without seeding trial or benchmark. Observations made by about 20 researchers in the period July-December 1998.

The parameter used is the value of SGOT and SGPT. SGPT is an enzyme produced by hepatocytes, the many types of cells found in the liver. SGPT level in the blood will increase in line with damage to the hepatocytes cells that can occur due to hepatitis virus infection, alcohol, drugs that is induct the occurrence of damage to hepatocytes, and for others such as shock or drug poisoned.

SGPT values that are considered normal is 0 - 35 units per liter (u / l). Increased SGPT 50 times the value of the low indicates normal blood flow to the liver, hepatitis, or liver cell damage caused by the drug / chemical compound such as CCl4. Increased SGPT values can light up are caused by the hepatitis, cirrhosis, cancer and alcohol on the liver. Sometimes cirrhosis only occurs in the value of SGPT increased 2-4 times from the normal value.

SGOT while many organs found on the heart, liver, muscle order, pancreas, lungs, red blood cells and brain cells. When cells are damaged organs, the SGOT will be released in the blood. Result will be seen when measuring the amount of correlation or level of illness of the cells occurred. Normal SGOT values ranging from 3 - 45 units per liter (u / l). SGOT Increased value can be caused by the hepatitis C. In the acute hepatitis, an increase can occur up to 20 times their normal values.

The study shows, based on a statistical calculation, decrease the value of SGOT and SGPT significant. After 14 days therapy, the decline in value of the total patient SGOT to reach 2.89 times, while for SGPT reached 3.28 times compared to before treatment. The results do not differ greatly also found in individuals who suffer non-hepatitis and hepatitis. Hepatitis patients experienced a decrease of 3.48 times SGOT and SGPT was 3.82 times, compared to before treatment. Are on the individual non hepatitis, a decrease in SGOT occurred around 1.91 times and 2.15 times as much as SGPT.

Excavate Other Benefits

Up to now, many studies have been conducted to try to get benefit from this valuable tubers. Studies of the incentive is to be seen as an anti tumor benefit curcumin to treat cancer disease. Numerous reports indicate, kurkumoid including curcumin have chemo preventive and curative activity against cancer. Studies are generally conducted on the animal experiment with the different routes and tested with the system in vitro.

However, few studies have also been started recently conducted in humans.
Another benefit that is also being spied on from curcumin is retardation of the replication Human Immunodeficiency Virus (HIV). A study shows, curcumin prevent the fusion of virus in the cell cycle of HIV replication. Various studies conducted to continue to explore the point of light. If all of the clinically evident, the plants that contain curcumin will benefit the rich.

Source: Farmacia Magazine



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